Homelessness and health-related outcomes in the Republic of Ireland: a systematic review, meta-analysis and evidence map

Aim To map existing research on homelessness and health in the Republic of Ireland, and to synthesize the evidence on housing-related disparities in health. Methods Peer-reviewed articles and conference abstracts published in English between 2012–2022 were retrieved from 11 bibliographic databases if they contained empirical data on homelessness and health in Ireland, and – in a subsequent screening stage – at least one measure of health disparity between the homeless and general populations. Reviewers extracted relative risks (RR), 95% confidence intervals (CI), and calculated pooled RR of comparable health disparities using pairwise random-effects meta-analyses. Results One hundred four articles contained empirical data on the health of homeless individuals residing in Ireland, addressing primarily substance use, addiction and mental health. Homelessness was associated with increased risk of illicit drug use (RR 7.33 [95% CI 4.2, 12.9]), reduced access to a general practitioner (GP) (RR 0.73 [CI 95% 0.71, 0.75]), frequent emergency department (ED) presentation (pooled RR 27.8 [95% CI 4.1, 189.8]), repeat presentation for self-harm (pooled RR 1.6 [95% CI 1.2, 2.0]) and premature departure from hospital (pooled RR 2.65 [95% CI 1.27, 5.53]). Conclusions Homelessness in Ireland is associated with reduced access to primary care and overreliance on acute care. Chronic conditions amongst homeless individuals are understudied. Supplementary Information The online version contains supplementary material available at 10.1007/s10389-023-01934-0.


Introduction
Homelessness levels continue to rise in most parts of Europe with children and adolescents, migrants, ethnic minorities, women, and families at increasing risk (European Commission 2022). The Republic of Ireland is unique in the severity of recent national spikes in homelessness (Allen et al. 2020). According to official administrative data, the number of people staying in overnight emergency accommodation more than doubled in Ireland since 2015, reaching a record high of 7917 adults and 3480 children in October 2022 (Department of Housing, Local Government and Heritage 2022). The number of families who are homeless increased by 300% (Long et al. 2019). These figures do not account for 'hidden homelessness' (Allen et al. 2020); an estimated 290,000 adults slept in their cars, in squats, on the floors or sofas of family and friends, or in unsafe accommodation in 2022 (~6% of Irish population) (RED C and Simon Community 2022). Such trends come at high social and personal cost. Individuals and families experiencing homelessness face discrimination, isolation, barriers to accessing public services, and in turn, health disparities (European Commission 2022).
Health disparities are chains of events signified by differences in environment, access to, utilization of, and quality of care, overall health status, or a particular health outcome (Carter-Pokras and Baquet 2002). These differences encompass health inequalities (i.e. variation in health status or outcomes) and inequities (i.e. variation in the distribution or allocation of resources), and adversely affect groups of people who experience greater social or economic obstacles to health based on race or ethnicity, religion, socioeconomic status (SES), gender, age, disability, geographic location, sexual orientation, or other characteristics historically linked to discrimination or exclusion (Klein and Huang 2010). The mechanisms leading to disparities in health are complex. Structural, place-based, and individual factors such as concentrated poverty, proximity to environmental hazards, access to healthcare, stress and lifestyle risk factors intersect and contribute to adverse health outcomes in marginalized populations (Fazel et al. 2014;Ingram et al. 2021). Social exclusion, by determining access to education and employment opportunities, impedes economic opportunity. SES, in turn, shapes material circumstances and health risk behaviours contributing to overall health and well-being (World Health Organization 2010). Woodward and Kawachi (2000) argue that resulting health inequalities are unjust, avoidable, expensive and detrimental to all members of society (Woodward and Kawachi 2000).
Health disparities amongst individuals experiencing homelessness have been widely documented. Homeless individuals in high-income countries have higher rates of suicide and unintentional injuries and an increased prevalence of a range of infectious diseases, mental disorders and substance misuse (Fazel et al. 2014). High rates of age-related conditions (functional and cognitive impairments and falls) have been documented (Brown et al. 2012), as have increased morbidity and mortality from cardiovascular diseases linked with behavioural risk factors such as illicit drug and/or tobacco use, and poor access to early care (Jones et al. 2009). Homeless individuals have higher rates of hospital admission and longer stays once admitted (Hwang et al. 2013) but are less likely to engage with preventive health services or adhere to medication (Fazel et al. 2014). These factors contribute to premature mortality. In Dublin, standardized mortality ratios (SMRs) were 3-10 times higher in homeless men and 6-10 times higher in homeless women compared with the general population between 2011 and 2015, with overdose related to substance use the leading cause of death (Ivers et al. 2019).
In Ireland, because there is currently no mechanism for linking homelessness and health outcomes data, understanding housing-related health disparities requires synthesizing empirical evidence from individual studies. To date, only one review of literature has been conducted relating to homelessness and health in the Republic of Ireland. McNeill et al. (2022) reviewed access to healthcare for people experiencing homelessness in the UK and Ireland (McNeill et al. 2022), identifying a need for improved staff education, flexibility of systems, service coordination, patient preparedness and holistic care across the two countries. Also in 2022, Health Service Executive Ireland (HSE) documented a need for improved supports across healthcare services for homeless people who experience chronic and complex health conditions, especially those persistently homeless, sleeping rough, or with substance use disorders (Health Services Executive Ireland 2022). Meeting and monitoring these needs first requires understanding baseline differences in health and healthcare outcomes; a task of particular urgency in light of Ireland's ongoing housing crisis and sustained increases in homelessness (Department of Housing, Local Government and Heritage 2022), evidence that disparities in mortality between homeless and housed people are worsening over time (Ivers et al. 2019), and the recent entrenchment of said disparities during the COVID-19 pandemic (Corey et al. 2022).
To facilitate discussion regarding directions for targeted research and interventions, the two primary aims of this study are to provide an overview of research on the relationship between homelessness and health in the Republic of Ireland, and to synthesize the existing evidence on housingrelated disparities in health status, and health care access and use. We include both objectives because -in addition to the identification of health disparities -the review will identify the extent to which research exists to address them.

Search strategy
This systematic review was registered to PROSPERO (ID: CRD42022348943) (Ingram and Perrotta 2022), conducted in accordance with Cochrane guidelines , and reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement (Additional File 1) (Page et al. 2021). Articles were retrieved on 18 November 2022 through a keyword search in 11 bibliographic databases: PsychInfo, PsychArticles, Cochrane library, PubMed, Embase, CINAHL, Web of Science, Social Sciences (Full Text), Econlit, Scopus, and Academic Search Complete. Search terms related to health (health* OR risk OR disease OR mortality), homelessness (homeless* OR 'insecure housing' OR 'unstable housing' OR 'precarious housing'), and the Republic of Ireland (Ireland* OR Irish). Searches were restricted to articles published since January 2012 to correspond with the dates for which official homelessness data exists in Ireland (Department of Housing, Local Government and Heritage 2022).

Study selection
Identified citations were collated, uploaded into Rayyan (Ouzzani et al. 2016), and duplicates removed. Initial screening included any peer-reviewed article or conference abstract in English with empirical data on health status, or health care access or use, of individuals experiencing homelessness in Ireland. Under Ireland's Housing Act 1988, homelessness is defined as (1) having no accommodation available that can reasonably be stayed in or living in a hospital, county home, night shelter or other such institution, and (2) being unable to provide accommodation from one's own resources (Government of Ireland 1988). One researcher screened titles and abstracts and two researchers independently screened remaining full texts to exclude articles conducted outside of the Republic of Ireland, without an empirical component, or not related to homelessness and health. References from relevant articles and systematic reviews were reviewed for eligibility. The aim of this initial screen was to map existing qualitative and quantitative evidence on the health of individuals experiencing homelessness in Ireland.
In a second screening stage, two researchers independently re-examined the full texts of included articles to identify quantitative studies containing a method for comparing at least one health indicator between individuals experiencing homelessness and the general population in Ireland. As the measurement of health disparities requires accounting for group size (Penman-Aguilar et al. 2016), studies with incomplete denominators in the homeless and/or reference group were excluded. Complete study selection criteria are shown in Additional File 2. Disagreements that arose between reviewers at each stage of the selection process were resolved through discussion.

Data extraction and analysis
Data from all studies meeting first-round inclusion criteria were extracted into a database in Excel describing study design and location, sample size, health topic(s) addressed, whether articles focused on health status or health care access, quality, or use, and additional keywords (Additional File 3). Reasons for inclusion/exclusion in further quantitative synthesis were marked as 'include', 'qualitative', 'no comparison data', or 'missing denominator(s)'. A separate database was created for articles meeting second-round inclusion criteria in which the sampled population, study design, health indicator of interest, and method for measuring and analysing disparity were recorded (Additional File 4). Where possible, reviewers extracted two-by-two table contents for relevant indicators and calculated relative risk (RR), absolute risk reduction (ARR) and 95% confidence intervals (CI). Continuous measures of effect were recorded as mean and standard deviation (SD) in the homeless and non-homeless groups, or recorded as reported by study authors (e.g. SMR, incidence rate ratio (IRR), percent increase over time).
Studies with comparable outcome measures and study populations were included in meta-analyses. Pairwise random-effects meta-analyses were performed using the Der-Simonian-Laird method to estimate the pooled RR of comparable health outcomes in the homeless vs. non-homeless population. Cochran's Q test was performed to estimate whether total variation differed significantly from expected variation. τ 2 (T2) and I 2 statistics estimated between-study variance, with I 2 > 75% indicating 'high' heterogeneity (Deeks et al. 2022). All data were analysed in R version 4.0.2 (Balduzzi et al. 2019).

Quality assessment
Strength of study design was assessed using a quality checklist adapted from other systematic reviews (Harden et al. 2004;De Silva et al. 2005;Cook et al. 2013). Studies measuring health disparities were given a score from 0 to 5 based on the following criteria: (1) sample selected was something other than a convenience sample to reduce sample selection bias and allow for generalizability to a larger population; (2) clear description of methods used to collect, analyse data, and assess disparities; (3) attempt made to establish nonself-reported/objective assessment of the data; reliability and validity of the data; (4) sampled from multiple sites/communities/localities (rather than one site) to increase sample representativeness; and (5) sufficient sample size and standard errors accurately reported.

Map of existing research on homelessness and health in Ireland
Of the 584 non-duplicate records published since 2012 identified via bibliographic databases, 104 contained empirical data on the health of homeless individuals residing in the Republic of Ireland (Fig. 1). These are listed and numbered M1 to M104 in Additional File 5.
One fifth of included records were conference abstracts (N = 20). Studies were primarily cross-sectional (N = 33), retrospective reviews (N = 20), or of qualitative design (N = 23). Ten studies employed mixed methods (e.g. Specific health topics addressed in each article are displayed in Table 1    The complete database of included studies is available as Additional File 3 along with descriptions of included variables.

Study characteristics
The second-screening stage identified 14 peer-reviewed studies and three conference abstracts with indicators of health disparities published between 2014 and 2022 (Table 2) In terms of study quality, publications met between zero [M80, M84] and all five criteria [M32, M41, M42, M48] (Mean = Median = 3). The most common limitations were using a convenience sample and sampling from one site. Complete quality checklists are presented in Additional File 4.
Health disparities reported were grouped into six categories: substance misuse, mental health and self-harm, health care use, health care access, physical health status, and social determinants of health. The researchers were able to extract two-by-two  (Fig. 3).

Substance misuse
Homelessness, when compared to the general population, was associated with a significantly higher risk of having misused alcohol in one's lifetime (N = 276;RR 5.8 [95% CI 3.5,9.6   PR, peer-reviewed, CA, conference abstract, ED, emergency department, CT, computerised tomography a Quality Checklist includes: (1) sample selected using something other than a convenience sample, (2) clear description of methods, (3) non-self-report/objective assessment, (4) sampled from multiple sites/communities/localities, (5) sufficient sample size    Once admitted to hospital, homeless patients had shorter hospital stays on average (9.41 ±18.2 vs. 12.2 ±24.9) but occupied 15 times more bed days per capita of the catchment population (4.4 vs. 0.3 days/person/annum) (N = 5114) [M57]. Across studies, homelessness was associated with a higher risk of leaving the ED before being seen or of selfdischarge once admitted (N = 155,269; pooled RR 2.65 [95% CI 1.27, 5.53]; Fig. 3). For ED attenders younger than 16, homelessness was associated with lower risk of presenting for injury or 'being well', and higher risk of presenting for respiratory viral, wheezing or gastro (N = 4638) [M58]. Homeless adult attenders were less likely to present for abdominal pain, chest pain or shortness of breath, and more likely to present for head injury or collapse (N = 47,062) [M57]. Upon admission, homelessness was positively associated with diagnoses of pneumonia/bronchitis, cellulitis, and seizure (N = 7031; see Additional File 6 for specific effect measures) [M57].

Health care access
Only one study reported disparities in healthcare access (

Physical health status
Studies conducted by Crowley et al. (2017) and Giese et al. (2015) in cohorts of PWID did not reveal significant differences in the prevalence of fibrosis, liver disease (N = 59), nor HIV positivity (N = 53) according to housing status [M76, M79]. Homeless parents surveyed in ED triage were more likely to report that their housing situation negatively impacted their child's physical health (N = 312; RR 3.9 [95% CI 2.0, 7

Study scope and quality
Our initial overview of research on homelessness and health in Ireland identified 104 studies, nearly half of which focused on substance use, addiction, and mental health. Of these, 17 studies reported disparities in health or healthcare-related outcomes, revealing associations between homelessness and substance misuse, self-harm presentations to ED, psychiatric admission, reduced access to GP, frequent ED presentation, premature departure from hospital, and increased risk of hospitalisation due to VTE, pneumonia/bronchitis, cellulitis, and seizure. That half of studies reporting health disparities were retrospective reviews is not surprising given the availability of hospital admissions data. Populationbased health data such as disease registers can be difficult to access and/or to link with homelessness data due to lack of a unique health identifier (Moran 2016). As a result, we found that researchers outside of the acute care setting relied on surveys to assess differences in health, potentially biasing results due to convenience sampling, sample size, or self-report data. These limitations are not unique to Ireland. An international umbrella review of studies investigating associations between homelessness and any health outcome found only two meeting criteria for 'convincing evidence' as of 2021 (Fornaro et al. 2022). Authors found -as did we -a tendency for small sample sizes and high heterogeneity between studies.
Without comprehensive, accessible data, our review reveals a currently incomplete understanding of housingrelated health disparities in Ireland. Moving forward, the usage of unique identifiers and linkage of health and social care data should be prioritized, as should the routine recording of housing status in primary care, hospital datasets, and national disease registries. Examples of successful linkages of homelessness and health datasets exist from Scotland and the US (Waugh et al. 2018;Trick et al. 2021).

Substance misuse
Findings from our review are in line with international evidence, pointing to the disproportionate risk of alcohol and drug misuse amongst homeless individuals compared to the general population (Fazel et al. 2014) [M48,M88]. As of 2015, disparities in SMR calculated by Ivers et al. (2019) were largely attributable to drug and alcohol use [M48]. Though the proportion of substance-use related homeless deaths in the US was comparable to Ireland that same year (~30%) it has since skyrocketed to 82% due to proliferation of synthetic opioids, underlining the increasing severity of this crisis internationally (Cawley et al. 2022). Encouragingly, we found a growing body of research from Ireland focused on improving the quality and availability of addiction care and supports. Studies demonstrate the success of the Housing First vs. Traditional Staircase approach [M9-16], of creating a continuum of care for service users across all addiction and homeless services [M18], and of lowering thresholds to methadone provision, benzodiazepine provision, and naloxone availability [M19]. Less encouraging are lags in subsequent policy change and implementation. Ireland's first Supervised Injection Facility was approved in 2015, for example, but none are operative as of 2023 (Harm Reduction International 2022; Health Services Executive Ireland 2023). We identified one study examining barriers preventing the operationalisation of effective harm reduction strategies and how to overcome them [M19]. This remains an important direction for future research.

Mental Health
The fact that the association between homelessness and substance use was reduced/attenuated in cohorts of psychiatric inpatients (Fig. 3) aligns with evidence that a relationship between mental illness and substance use exists independently from homelessness (Maremmani et al. 2017). This brings to light the issue of dual diagnosis. The Irish mental health care system currently delineates between general and addiction psychiatric services, preventing individuals with both a substance misuse and mental health condition from accessing general mental health care (O'Carroll 2020). Individuals with a dual diagnosis are at higher risk of suicide, undoubtedly contributing to the disproportionate and increasing risk of self-harm and repeat self-harm presentation to ED identified amongst homeless cohorts included in this review [M32, M42]. However, homeless individuals presenting for self-harm (despite vulnerability to comorbid risk factors and repeat presentation) more frequently leave the ED without being seen [M41]. With a national model of integrated service provision for individuals with a dual diagnosis under development (Health Service Executive Ireland 2022), our review reveals a need for evidence relating to appropriate mental health care and support for homeless individuals with co-occurring substance use and mental health conditions.
It is also of note that studies reporting disparities in mental health status looked at risk of ED psychiatric referral ( Fig. 3) or differences in psychiatric inpatients according to housing status, but that mental health disparities were not assessed outside of the healthcare setting. Prinsloo et al. (2012) found that only 24% of residents surveyed in a Dublin homeless hostel with a mental disorder diagnosis were attending psychiatric or addiction services, indicating the potential for hospital/health care data to miss individuals less inclined or able to engage with the mental health care system [M28]. Globally, homeless individuals are at elevated risk of personality disorder, bipolar disorder, and post-traumatic stress disorder (Fazel et al. 2014) and approximately half suffer from depressive symptoms and/or psychosis (Ayano et al. 2021). This suggests the likely scope and severity of mental health inequalities in Ireland. However, because estimates differ substantially by study and by demographic factor, our review reveals a need for better quality measurements that identify inequity in mental health outcomes in order to target appropriate, early interventions. Critically, this too could contribute to the prevention of suicide and unintentional overdose.

Health care use
The most frequently reported disparities are related to ED presentations and hospital admissions. Included studies reported significantly elevated risk of ED attendance and frequent ED attendance, of leaving the ED without being seen, and -if admitted -of longer hospital stays amongst homeless individuals. Similar disparities have been widely reported internationally (Fazel et al. 2014;Vohra et al. 2022). However, a systematic review of homelessness and ED use found that the rate ratio of homeless vs housed ED visits reported by Ní Cheallaigh et al. (2017) was more than five times higher than results from comparable studies conducted in the US (Vohra et al. 2022). One explanation might be that the Dublin study was conducted most recently [M57], and that rates of ED attendance are increasing faster in homeless populations both in Ireland and abroad (Vohra et al. 2022) [M58]. Regardless, consensus across Irish studies regarding disproportionate rates of frequent ED attendance and premature departure (Fig. 3) demonstrate a problematic overreliance on acute care in a population with access to free primary and secondary healthcare [M63].
Studies in our evidence map offer some explanation. People experiencing homelessness have recurrent interactions with health professionals that leave them feeling excluded, discouraged, and more inclined to self-exclude from primary care [M54]. Once in hospital, homeless patients have reported lack of mental stimulation, insufficient detoxification programmes, poor communication by healthcare professionals, perceived discrimination associated with addiction, and lack of mental health supports as barriers to remaining in care [M55-56]. Dual diagnosis and substance use disorder are associated with after-hours visits to ED (Stenius-Ayoade et al. 2017), wait times can be long, and homeless patients may exhibit challenging behaviour that prevents staff from getting to examine underlying causes of repeat presentation [M54,M62]. Despite this evidence -and despite national recommendations for the identification of potential frequent attenders and development of patient-specific care plans as early as 2012 -our review confirms that stark disparities persist in the use of emergency care as of 2022 [M58].

Physical health
That only a small number of studies (N = 5) reported disparities in physical health reveals -as with mental health outcomes -a need for better quality measurements. Studies revealed the disproportionate risk of diagnoses associated with injecting drug use [M57, M92]. Nationally, risk of hospitalisation due to VTE was 10 times higher in homeless individuals compared to the general population in 2019 [M92]. Beyond mortality risk, this is of particular consequence as Carroll et al. (2021) reported shortages in availability of rehabilitation services in Ireland to treat mobility issues that may be brought on by VTE [M99]. That the risk of seizure diagnosis was four times greater in homeless individuals may be indicative of increased rates of traumatic brain injury [M57,M98]. Internationally, homelessness is associated with disproportionate rates of chronic liver disease, HIV, HCV, and tuberculosis (TB) (Fazel et al. 2014;Hashim et al. 2022). However, when controlled for intravenous drug use, studies included in our review revealed no significant differences in HIV positivity or risk of liver disease according to housing status [M76,M79]. We identified a significant body of literature on 'HepCare Ireland', a project that has been improving national HCV outcomes through multiple-level testing and treatment interventions since 2016 [M70], but did not find information on TB. The prevalence of diabetes is comparable to general population estimates (8%) [M94]. Whereas cardiovascular diagnoses in hospital are less common [M57] despite evidence from Europe and Canada that homeless individuals have high rates of morbidity and mortality from cardiovascular disease (Fazel et al. 2014). Ní Cheallaigh et al. (2017 report increased risk of pneumonia/bronchitis diagnosis in hospital, but no differences in diagnoses of COPD or asthma [M57]. Rather than demonstrating baseline risk, disparities measured in an acute care setting may represent the fact that chronic conditions are more likely to be poorly controlled in homeless populations. Outside of the acute care setting, common physical health problems in homeless individuals include skin, dental, eye, joint, and asthma [M63, M95-96]. These rates have not been compared to the general population.

Social Determinants of Health
Studies included in this review demonstrate higher rates of social exclusion amongst homeless cohorts [M37, M80, M84]. In Ireland as abroad, lack of housing reportedly negatively impacts child social development and levels of social support in adulthood, both factors that impact health and are aggravated by health status (Hwang et al. 2009) While not the aim of this review, it is imperative to recognize how SDOH lead to homelessness. Myriad factors -unemployment and poverty, migration, ageing, health or relationship difficulties, lack of affordable housing, and/or inadequate support when leaving care facilities or public institutions -can drive someone into precarious housing. In Ireland, for example, young people are discharged from care at age 18 and face sudden withdrawal of supports (Mayock et al. 2013). Many have developed drug and alcohol dependencies by this time and may struggle to find permanent housing [M81], beginning to explain the relationship between being in state care as a child and homelessness identified in this review [M88]. Encouragingly, we found a number of studies addressing homelessness as a combined medical and social issue in Ireland [M80-87]. One promising result is a national shift towards Housing First models of care [M9-16]. As well, research and practice can benefit from considering the health enabling traits related to homelessness such as high resiliency and survival skills (Lee et al. 2011).
Further exploration of the finding that homelessness is associated with non-Irish ethnicity in child ED presentation reveals overrepresentation of Roma, Black, and -to a lesser extent -Irish Traveller presentations in the homeless cohort [M58]. This is in stark contrast with demographics of the general homeless population which is primarily White Irish (Central Statistics Office 2016). In 2018, a Roma national needs assessment identified barriers to accessing social and medical services due to lack of documentation to prove residency, language barriers, not knowing about services or how to access them, and experiences of discrimination (Pavee Point and Department of Justice and Equality 2018). These findings, coupled with disproportionate rates of ED attendance, reveal a manifest need to better understand the health care needs and patterns of use specific to homeless members of ethnic minority communities. Even more so because there is limited national data collection of ethnicity, and ethnic/ birth information is often missing from electronic medical records (Hannigan et al. 2019)[M58]. Our review identified no studies focused on the intersectionality of ethnicity, homelessness, and health in Ireland.

Limitations & Strengths
It is important to note the limitations inherent to the exclusion of grey literature from this review. HSE Social Inclusion, Regional Homeless Executives, and non-profit organisations such as Simon Communities, Focus Ireland, the Ana Liffey Drug Project, and Partnership for Health Equity are leading the charge in homeless health equity and regularly publish reports on the state of housing and health in Ireland that complement findings from peerreviewed literature. Another limitation is that this review did not report disparities in health according to age, gender, length of homelessness, or family status (single vs family homelessness); four factors known to significantly influence health outcomes (Ivers et al. 2019;O'Carroll 2020). Readers should be aware that the disparities reported apply predominately to homeless individuals linked with healthcare and may underestimate the severity of health difficulties facing those who are not. Finally, only a small number of studies could be included in meta-analyses due to variability of outcome variables and study populations. This resulted in small pools of comparable health outcomes (≤ 3) due to which meta-analytic results should be interpreted with caution.
Despite these limitations, this systematic review is an important contribution to the field as it provides the first map of evidence relating to homelessness and health in Ireland that can be used to inform and monitor future trends in research. By synthesizing existing evidence on housingrelated health disparities, the review can facilitate crosscountry and temporal comparisons in health outcomes and help guide the allocation of resources. Importantly, we have created two tools that can accelerate future searches for evidence. The first is a database of all relevant peer-reviewed studies and conference abstracts published since 2012 on homelessness and health in Ireland, indexed by Health Topic (Additional File 3). The second is a database containing all published, quantitative measures of homeless health disparities (Additional File 4).

Conclusion
This review provides the first overview of research on homelessness and health conducted in Ireland, revealing a growing body of evidence on substance use, mental health status and access to/quality of related care. Studies reporting health disparities reveal associations between homelessness and substance misuse, self-harm presentations to ED, psychiatric admission, reduced access to GP, frequent ED presentation, premature departure from hospital, and increased risk of hospitalisation due to VTE, pneumonia/bronchitis, cellulitis, and seizure. While lack of routinely collected, accessible data prevents a complete understanding of Ireland's status vis-à-vis homelessness and health equity, review findings shed light on an urgent need for more extensive harm reduction programmes, more appropriate mental health supports, and improved strategies for the identification and care of frequent ED attenders. Moving forward, national homelessness and health datasets should be expanded, linked, audited, and made more accessible. This will facilitate analysis of under-examined disparities in health relating to comorbid conditions, chronic and infectious diseases, and how ethnicity and SDOH interact with homelessness and health.